The Trans Directory
feat: add glossary, oestradiol/testosterone charts, and paper content
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content/ASSETS/typst/EUn-Paper/main.typ
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content/ASSETS/typst/EUn-Paper/main.typ
···
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#import "@preview/lilaq:0.5.0" as lq
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#import "@preview/dashy-todo:0.1.3": todo
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#import "@preview/orchid:0.1.0"
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#import "@preview/glossarium:0.5.10": make-glossary, register-glossary, print-glossary, gls, glspl
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#import "@preview/catppuccin:1.1.0": catppuccin, flavors
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#show: catppuccin.with(flavors.frappe)
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#show: make-glossary
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#let entry-list = (
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(
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key: "E2",
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long: "Oestradiol",
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description: [#link("https://en.wikipedia.org/wiki/Estradiol")[Oestradiol], also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone.]
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),
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(
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key: "T",
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long: "Testosterone",
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description: [#link("https://en.wikipedia.org/wiki/Testosterone")[Testosterone] is the primary male sex hormone and androgen in males]
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),
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(
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key: "eun",
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short: "EUn",
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long: "Estradiol undecylate",
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description: [
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#link("https://en.wikipedia.org/wiki/Estradiol_undecylate")[Estradiol undecylate], also known as estradiol undecanoate is a lesser used ester of #link("https://en.wikipedia.org/wiki/Estradiol")[Oestradiol]. Typically taken on a 30 day injection cycle, also taken in a shorter 14 day injection cycle.
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],
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),
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// Add more terms
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)
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#register-glossary(entry-list)
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#set quote(block: true)
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#show quote: set align(center)
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#show quote: set pad(x: 5em)
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//#import "@preview/catppuccin:1.1.0": catppuccin, flavors
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//#show: catppuccin.with(flavors.frappe)
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// if you do not want to use the integrated packages, you can comment out the following lines
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#import "extra.typ": *
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#show: great-theorems-init
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···
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// Body typography (applies to both modes)
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body-line-leading: 1.32em, // main-text line height
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body-paragraph-spacing: 0.7em, // spacing between main-text paragraphs
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body-paragraph-spacing: 2em, // spacing between main-text paragraphs
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body-text-spacing: 106%, // glyph tracking for the body text
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bibliography: bibliography(
···
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#outline(title: "TODOs", target: figure.where(kind: "todo"))
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= Abstract
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#lorem(30)
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#lorem(5)
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#todo(position: "inline")["Start Abstract"]
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= Introduction
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#lorem(10)
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#lorem(5)
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#todo(position: "inline")["Start Introduction"]
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= Methods
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#lorem(10)
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Frequent blood tests where taken, every 1 to 2 weeks depending on avaliability of my GP, in order to map out the trend of my #gls("E2") levels through out the usual injection cycle of #gls("eun") which is 30 days.
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I sampled my lowest #gls("E2") either on the day of my injection or the day before when my injection day landed on a Sunday as my local pathology lab was closed.
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#todo(position: "inline")["Expand on my method as I continue researching"]
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== Target Range
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In this paper I will mention a "target range" in a few places, depending on what you've been taught or where you look this can mean several different things! I will list a few examples that are most common and explain my target and teh reasoning behind it.
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=== AuthPATH guidelines:
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#quote(attribution: [@auspath-e2-level-rec])[
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"For those wishing to have complete testosterone suppression, the total testosterone target is < 2 nmol/L. [...] AusPATH SOC 2025 recommends maintaining estradiol concerntrations above 250 pmol/L, in accordance with Cheung et al."
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]
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=== Cheung et al:
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AusPATH SOC 2025 mentions the following target ranges:
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#quote(attribution: [@position-statement-hormonal-management])[
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"We recommend targeting estradiol levels of 250–600 pmol/L and total testosterone levels < 2 nmol/L"
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]
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== WPATH Standards of Care, Version 8
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#quote(attribution: [@wpath-e2-level-rec])[
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"Serum testosterone levels should be less than 50 ng/dL."
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"Serum estradiol should be in the range of 100-200 pg/mL."
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]
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// look at "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society* Clinical Practice Guideline" https://academic.oup.com/jcem/article/102/11/3869/4157558
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#todo(position: "inline")["list more target ranges"]
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#todo(position: "inline")["Define my target range"]
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= Results
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in @heam-levels we look at my haemoglobin levels(grams per litre) from weekly blood tests
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== Overall levels
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#let (x-heam, y-heam) = lq.load-txt(read("heamoglobin.csv"))
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in @all-e2-levels we look at my #gls("E2") levels(pmol per litre) over the entire course of this research.
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#figure(
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lq.diagram(
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width: 100%,
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height: 8cm,
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title: [HAEMOGLOBIN],
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ylabel: "g/L",
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xlabel: "week",
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title: [OESTRADIOL],
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ylabel: "pmol/L",
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xlabel: "date",
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xaxis: (tick-distance: 1),
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lq.plot(
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x-heam,
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y-heam,
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(
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datetime(year: 2026, month: 2, day: 06),
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datetime(year: 2026, month: 2, day: 13),
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datetime(year: 2026, month: 2, day: 20),
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),
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(1189, 906, 496),
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smooth: false,
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mark: "s",
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label: [E2]
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),
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),
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caption: [Weekly haemoglobin levels],
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)<heam-levels>
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caption: [Overview of all #gls("E2") levels during this research],
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)<all-e2-levels>
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== The first week
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in @first-e2-levels we look at the very first 30 days after taking #gls("eun").
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The test taken on the first injection day, #datetime(day: 6, month: 2, year: 2026).display(), shows my trough levels at the end of an EEn injection cycle with 5mg of EEn#footnote([Simulated injection cycle for reference: #link("https://estrannai.se/#i1_cu,5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-4,7,2-5,7,2-5,7,2-5,7,2_c,5,7,2")]) but before the initial injection of #gls("eun").
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The first injection was an injection of 16mg, this was origionally done in error as I read the wrong value in my early research. Continuing this dose size would have caused substancially lower #gls("E2") levels than desired#footnote([Simulated values continuing this cycle: #link("https://estrannai.se/#it1_cu,5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-16,7,5-16,30,5-16,30,5-16,30,5-16,30,5-16,30,5-16,30,5-16,30,5_cu,16,30,5")]).
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#figure(
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lq.diagram(
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width: 100%,
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height: 8cm,
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title: [OESTRADIOL],
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ylabel: "pmol/L",
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xlabel: "date",
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xaxis: (tick-distance: 1),
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lq.plot(
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(
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datetime(year: 2026, month: 2, day: 06),
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datetime(year: 2026, month: 2, day: 13),
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datetime(year: 2026, month: 2, day: 20),
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),
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(1189, 906, 496),
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smooth: false,
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mark: "s",
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label: [E2]
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),
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),
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caption: [The first 30 days of #gls("E2") after starting #gls("eun")],
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)<first-e2-levels>
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#quote(attribution: [@why-dont-we-want-zero-testosterone])[
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"...near-zero testosterone (less than 10 ng/dl, or 0.35 nmol/L) can cause issues..."
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]
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#figure(
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lq.diagram(
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width: 100%,
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height: 8cm,
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title: [TESTOSTERONE],
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ylabel: "nmol/L",
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xlabel: "date",
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xaxis: (tick-distance: 1),
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lq.plot(
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(
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datetime(year: 2026, month: 2, day: 06),
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datetime(year: 2026, month: 2, day: 13),
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datetime(year: 2026, month: 2, day: 20),
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),
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(0.7, 0.6, 0.5),
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smooth: false,
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mark: "s",
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label: [T]
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),
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),
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caption: [The first 30 days of #gls("T") after starting #gls("eun")],
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)<first-T-levels>
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From this point forward I moved to 32mg injection cycle as shown in @dosing-examples. This generally should bring my #gls("E2") levels to the recomended range#footnote([Simulation of #gls("E2") levels after sapping from the 16mg injection to continuous 32mg injections: #link("https://estrannai.se/#it1_cu,5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-5,7,2-16,7,5-32,30,5-32,30,5-32,30,5-32,30,5-32,30,5-32,30,5-32,30,5_cu,32,30,5")]).
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#figure(
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image("./Injection-Monotherapy-dosing.png", width: 80%),
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caption: [
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Dosages for estradiol injections @injection-monotherapy-dosing
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]
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)<dosing-examples>
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= Discussion
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#lorem(20)
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#lorem(5)
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#todo(position: "inline")["Start Discussion"]
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= Conclusions
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#lorem(20)
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#lorem(5)
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#todo(position: "inline")["Start Conclusion"]
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= Acknowledgements
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#lorem(20)
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#lorem(5)
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#todo(position: "inline")["Start Acknowledgements"]
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= Glossary
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#print-glossary(
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entry-list
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)
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