The Trans Directory
style: fix Typst formatting and trailing commas in main.typ
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content/ASSETS/typst/EUn-Paper/main.typ
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content/ASSETS/typst/EUn-Paper/main.typ
···
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#import "@preview/lilaq:0.5.0" as lq
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#import "@preview/dashy-todo:0.1.3": todo
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#import "@preview/orchid:0.1.0"
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#import "@preview/glossarium:0.5.10": make-glossary, register-glossary, print-glossary, gls, glspl
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#import "@preview/glossarium:0.5.10": gls, glspl, make-glossary, print-glossary, register-glossary
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#show: make-glossary
···
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(
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key: "E2",
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long: "Oestradiol",
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description: [#link("https://en.wikipedia.org/wiki/Estradiol")[Oestradiol], also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone.]
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description: [#link("https://en.wikipedia.org/wiki/Estradiol")[Oestradiol], also called oestrogen, oestradiol, is an estrogen steroid hormone and the major female sex hormone.],
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),
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(
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key: "T",
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long: "Testosterone",
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description: [#link("https://en.wikipedia.org/wiki/Testosterone")[Testosterone] is the primary male sex hormone and androgen in males]
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description: [#link("https://en.wikipedia.org/wiki/Testosterone")[Testosterone] is the primary male sex hormone and androgen in males],
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),
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(
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key: "eun",
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short: "EUn",
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long: "Estradiol undecylate",
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description: [
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#link("https://en.wikipedia.org/wiki/Estradiol_undecylate")[Estradiol undecylate], also known as estradiol undecanoate is a lesser used ester of #link("https://en.wikipedia.org/wiki/Estradiol")[Oestradiol]. Typically taken on a 30 day injection cycle, also taken in a shorter 14 day injection cycle.
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#link("https://en.wikipedia.org/wiki/Estradiol_undecylate")[Estradiol undecylate], also known as estradiol undecanoate is a lesser used ester of #link("https://en.wikipedia.org/wiki/Estradiol")[Oestradiol]. Typically taken on a 30 day injection cycle, also taken in a shorter 14 day injection cycle.
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],
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),
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// Add more terms
···
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name: "Aria Quinlan",
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affiliation: "trans-info.aria.coffee",
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email: "hello@aria.coffee",
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note: [#orchid.generate-link("0009-0004-6743-0109", format: "full",name: "Aia Quinlan")],
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note: [#orchid.generate-link("0009-0004-6743-0109", format: "full", name: "Aia Quinlan")],
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),
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),
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date: "Febuary 2026", // version/date string (shown in both modes)
···
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=== AuthPATH guidelines:
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#quote(attribution: [@auspath-e2-level-rec])[
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"For those wishing to have complete testosterone suppression, the total testosterone target is < 2 nmol/L. [...] AusPATH SOC 2025 recommends maintaining estradiol concerntrations above 250 pmol/L, in accordance with Cheung et al."
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"For those wishing to have complete testosterone suppression, the total testosterone target is < 2 nmol/L. [...] AusPATH SOC 2025 recommends maintaining estradiol concerntrations above 250 pmol/L, in accordance with Cheung et al."
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]
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=== Cheung et al:
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AusPATH SOC 2025 mentions the following target ranges:
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#quote(attribution: [@position-statement-hormonal-management])[
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"We recommend targeting estradiol levels of 250–600 pmol/L and total testosterone levels < 2 nmol/L"
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"We recommend targeting estradiol levels of 250–600 pmol/L and total testosterone levels < 2 nmol/L"
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]
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== WPATH Standards of Care, Version 8
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#quote(attribution: [@wpath-e2-level-rec])[
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"Serum testosterone levels should be less than 50 ng/dL."
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"Serum testosterone levels should be less than 50 ng/dL."
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"Serum estradiol should be in the range of 100-200 pg/mL."
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"Serum estradiol should be in the range of 100-200 pg/mL."
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]
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// look at "Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons: An Endocrine Society* Clinical Practice Guideline" https://academic.oup.com/jcem/article/102/11/3869/4157558
···
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xaxis: (tick-distance: 1),
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lq.plot(
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(
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datetime(year: 2026, month: 2, day: 06),
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datetime(year: 2026, month: 2, day: 13),
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datetime(year: 2026, month: 2, day: 20),
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),
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(1189, 906, 496),
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datetime(year: 2026, month: 2, day: 06),
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datetime(year: 2026, month: 2, day: 13),
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datetime(year: 2026, month: 2, day: 20),
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),
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(1189, 906, 496),
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smooth: false,
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mark: "s",
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label: [E2]
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label: [E2],
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),
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),
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caption: [Overview of all #gls("E2") levels during this research],
···
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xaxis: (tick-distance: 1),
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lq.plot(
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(
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datetime(year: 2026, month: 2, day: 06),
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datetime(year: 2026, month: 2, day: 13),
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datetime(year: 2026, month: 2, day: 20),
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),
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(1189, 906, 496),
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datetime(year: 2026, month: 2, day: 06),
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datetime(year: 2026, month: 2, day: 13),
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datetime(year: 2026, month: 2, day: 20),
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),
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(1189, 906, 496),
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smooth: false,
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mark: "s",
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label: [E2]
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label: [E2],
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),
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),
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caption: [The first 30 days of #gls("E2") after starting #gls("eun")],
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)<first-e2-levels>
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#quote(attribution: [@why-dont-we-want-zero-testosterone])[
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"...near-zero testosterone (less than 10 ng/dl, or 0.35 nmol/L) can cause issues..."
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"...near-zero testosterone (less than 10 ng/dl, or 0.35 nmol/L) can cause issues..."
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]
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#figure(
···
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xaxis: (tick-distance: 1),
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lq.plot(
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(
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datetime(year: 2026, month: 2, day: 06),
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datetime(year: 2026, month: 2, day: 13),
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datetime(year: 2026, month: 2, day: 20),
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),
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(0.7, 0.6, 0.5),
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datetime(year: 2026, month: 2, day: 06),
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datetime(year: 2026, month: 2, day: 13),
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datetime(year: 2026, month: 2, day: 20),
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),
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(0.7, 0.6, 0.5),
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smooth: false,
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mark: "s",
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label: [T]
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label: [T],
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),
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),
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caption: [The first 30 days of #gls("T") after starting #gls("eun")],
···
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image("./Injection-Monotherapy-dosing.png", width: 80%),
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caption: [
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Dosages for estradiol injections @injection-monotherapy-dosing
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]
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],
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)<dosing-examples>
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= Discussion
···
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= Glossary
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#print-glossary(
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entry-list
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entry-list,
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)
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